Symbol
Name
ID

Lepr
leptin receptor
MGI:104993

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Type II diabetes mellitus
Disease(s) Associated with LEPR	Diabetes mellitus	Type II diabetes mellitus
coronary artery disease
type 2 diabetes mellitus

Mouse Phenotypes

increased pancreatic islet cell apoptosis

abnormal exocrine pancreas morphology

endocrine/exocrine gland phenotype

abnormal adrenal gland zona reticularis morphology

absent adrenal medulla

enlarged adrenal glands

abnormal pancreatic islet morphology

increased pancreatic alpha cell number

abnormal pancreatic beta cell morphology

increased pancreatic beta cell mass

increased pancreatic beta cell number

degranulated pancreatic beta cells

pancreatic islet hyperplasia

decreased somatotroph cell number

small male preputial gland

small seminal vesicle

decreased corpora lutea number

decreased mature ovarian follicle number

increased glucagon secretion

abnormal pancreatic beta cell physiology

abnormal insulin secretion

decreased insulin secretion

increased insulin secretion

abnormal lactation

abnormal pancreas physiology

pancreas inflammation

periinsulitis

Availability

Mouse Genotype

Lepr^db-2J/Lepr^db-2J

Lepr^db-3J/Lepr^db-3J

Lepr^db-5J/Lepr^db-5J

Lepr^db-9J/Lepr^db-9J

Lepr^db-rtnd/Lepr^db-rtnd

Lepr^db/Lepr^db

Lepr^m1Clo/Lepr^m1Clo

Lepr^{tm1b(EUCOMM)Wtsi}/Lepr^{tm1b(EUCOMM)Wtsi}

Lepr^tm1Jke/Lepr^tm1Jke

Lepr^tm1Mgmj/Lepr^tm1Mgmj

Lepr^tm2Mgmj/Lepr^tm2Mgmj

Lepr^tm5Mgmj/Lepr^tm5Mgmj

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Syn1-cre)671Jxm/0 (conditional)

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Gh1-cre)bKnmn/0 (conditional)

Lepr^tm1Jke/Lepr^tm1Jke
Tg(Pomc1-cre)16Lowl/0 (conditional)

Lepr^tm1.1Chua/Lepr⁺
Tg(Gh1-cre)bKnmn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23